Challenge #25 Salicyclic acid [C6H4(OCOCH3)COOH] is the essential ingredient in one of today's most widely used medications throughout the world. It is used as an anti-inflammatory agent, an analgesic, an antipyretic, and topically as a keratolytic agent, an antiseptic and a fungicide. Originally derived from salicin, a glycoside found as a natural ingredient of several common plants, it is now prepared synthetically as acetylsalicyclic acid. Question #1 - From what natural source growing in thickets along river banks would native California Indians have obtained this useful medicine? Answer: From a willow tree (Salix spp) particularly from the bark. Correct answer received from: Jason Coffer, moledrain, Selena, Imo, Mike McKillop, Jennifer LeBlanc, Karen (with Lisa's help), Maria, Karen K, Diane Purves, David Joyce (2nd try), Ed Re., Patti, Erin, Skimil, Gorkem Golan, Mindy, Becky, brian, don w., Mike McCreary, Missy

Question #2 - In which modern over-the-counter medication commonly used for pain relief and fever reduction is synthetic salicyclic acid the sole active ingredient? Answer: Aspirin (Aspirin is sometimes included with other substances in certain medications in order to provide multiple benefits from one medication.) Correct answer received from: Jason Coffer, bobcat (youth), moledrain, Selena, Imo, Mike McKillop, Jennifer LeBlanc, Ryan (youth), Kayo (youth), Karen (with Lisa's help), J-dog, Karen K., bilbo, Diane Purves, David W. Joyce, Athena (youth), Ed Re., Goldfish, Patti, Erin, Tulika, Skimil, Gorkam Golan, Mindy, blw., Mr. Rogers, Colonel, Ladywolf, Shecat10, Becky, goat-tee, don w., Mike McCreary, Missy